2010•Journal of Hebei Normal University of Science & TechnologyRequires access

Immuneactivity of Propionibacterium Acnes Against Actinobacillus pleuropneumoniae Serotype 7 and 9 Infection in Mice

Wenyu Han

Abstract

Propionibacterium acnes(PA)could induce heterologous immunoprotection against Actinobacillus pleuropneumoniae(APP)serotypes 1 and 5 infection.In this study,mice were vaccinated by PA isolate S14 then challenged by APP serotype 7(CCVC-265)and serotype 9(CCVC-267).The result showed that the immune protection rate were 60% and 70% respectively.In this study mice were also vaccinated by Pig-Anti APP serum and then challenged by APP serotype 7 and 9.All the immune protection rate reached 100%.Serum antibody titers were measured by ELISA against the APP serotype 7 and 9 antigen.The average titers of anti-APP 7 and anti-APP 9 were 1 800 and 2 800 respectively.The results showed that PA could induce a promising protection against APP serotype 7 and 9 on mice.

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Key concepts: Serotype, Propionibacterium acnes, Actinobacillus pleuropneumoniae, Heterologous, Microbiology, Titer, Immune system, Actinobacillus