Evaluation of target-controlled infusion of rocuronium in different sex patients

Objective To evaluate the performance of target-controlled infusion system for rocuronium in different sex patients.Methods 60 patients(ASA Ⅰ~Ⅱ)scheduled for selective surgical procedure under general anaesthesia were studied.The patients were divided into two groups equally,Man group(Group M) and Woman group(Group W).The target effective site concentration of rocuronium for intubation was 6 in each group;and the target effective site concentration during operation was 0.8 μg/ml,and was increased or decreased by 0.2 μg/ml to maintain 10%≥T1/TC0.The effective time,recover time,target rocuronium concentrations and blood rocuronium concentrations were recorded in intubation(T1),20 min after TCI(T2),40 min after TCI(T3) and end of operation(T4).Results The effective time of group W was significant shorter than group M(P0.05).The recover time and recover index of group W were significant longer than group M(P0.05).Target rocuronium concentrations and Blood rocuronium concentrations of group M were significant higher than group W in T1,T2,T3 and T4(P0.05).Conclusion The influence of patients sex on TCI of rocuronium is significant,but the mechanism need to study further.