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2010•Shandong yiyaoRequires access

Expression and significance of CXCR4 and MMP-2 in human rectal tumors

Yulan Wang

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Abstract

Objective To investigate the expression of CXCR4 and matrix metalloproteinase-2(MMP-2) in human rectal tumors and to analyze the clinical significance.Methods Expression of CXCR4 and MMP-2 in 50 cases with rectal tumor were examined by immunohistochemistry method.Then to evaluate the relationship between CXCR4 and MMP-2 expression with clinical and pathological data in human rectal tumors.Results The positive expression of CXCR4 and MMP-2 in rectal cancer tissues were higher than those in normal rectal tissues(P0.01).The positive expression of CXCR4 and MMP-2 were positively correlated with Dukes stage,tumor's differentiation and lymph node metastasis.Conclusion CXCR4 and MMP-2 maybe relate with the infiltration and metastasis of rectalcarcinoma.

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What this paper is about

Objective To investigate the expression of CXCR4 and matrix metalloproteinase-2(MMP-2) in human rectal tumors and to analyze the clinical significance.Methods Expression of CXCR4 and MMP-2 in 50 cases with rectal tumor were examined by immunohistochemistry method.Then to evaluate the relationship between CXCR4 and MMP-2 expression with clinical and pathological data in human rectal tumors.Results The positive expression of CXCR4 and MMP-2 in rectal cancer tissues were higher than those in normal rectal tissues(P0.01).The positive expression of CXCR4 and MMP-2 were positively correlated with Dukes stage,tumor's differentiation and lymph node metastasis.Conclusion CXCR4 and MMP-2 maybe relate with the infiltration and metastasis of rectalcarcinoma.

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Available abstract

Objective To investigate the expression of CXCR4 and matrix metalloproteinase-2(MMP-2) in human rectal tumors and to analyze the clinical significance.Methods Expression of CXCR4 and MMP-2 in 50 cases with rectal tumor were examined by immunohistochemistry method.Then to evaluate the relationship between CXCR4 and MMP-2 expression with clinical and pathological data in human rectal tumors.Results The positive expression of CXCR4 and MMP-2 in rectal cancer tissues were higher than those in normal rectal tissues(P0.01).The positive expression of CXCR4 and MMP-2 were positively correlated with Dukes stage,tumor's differentiation and lymph node metastasis.Conclusion CXCR4 and MMP-2 maybe relate with the infiltration and metastasis of rectalcarcinoma.

Key concepts: Matrix metalloproteinase, CXCR4, Immunohistochemistry, Colorectal cancer, Pathological, Clinical significance, Infiltration (HVAC), Medicine

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