The clinical experience of early respiratory support in therapy of respiratory failure caused by acute poisoning

Objective To investigate the clinical therapeutic effect and security of early respiratory support in therapy of respiratory failure caused by acute poisoning. Method The clinical data of 95 patients with respiratory failure caused by acute poisoning, hospitalized in our hospital from January 2012 to February 2014 were collected retrospectively. In this study, there were 50 patients in experimental group received early mechanical ventilation according to clinical symptoms and respiratory monitoring indicators in the presence of the spontaneous breathing, and 45 patients in control group received endotracheal intubation within 5 minutes after the cessation of breathing. The clinical cure rate, ventilation time and the incidence of complications were analyzed and compared between two groups. Result The clinical cure rate of patients in experimental group [92.0%(46/50)] was significantly higher than that in control group [75.6%(34/45)](P = 0.028), and the ventilator using time of patients in experimental group [(47.3±8.2) hours] was also significant lower than that in control group [(86.5±10.8) hours](P 0.001); both the incidence of pulmonary infection and low blood pressure of patients in experimental group [58.0%(29/50), 4.0%(2/50)] were significant lower than that in control group[82.2%(37/45), 17.8%(8/45)](P = 0.010, P = 0.029). Conclusion Early respiratory support has excellent clinical therapeutic effect on respiratory failure caused by acute poisoning, which can not only increase the cure rate of rescue, but also reduce the incidence of ventilator-associated complications.