Effect of Rosuvastatin on Serum Inflammatory Factor and Carotid Intima-Media Thickness in Patients With Carotid Atherosclerosis

Objective:To explore the effect of rosuvastatin on serum lipids,inflammatory factors and carotid intima-media thickness(IMT)in patients with carotid atherosclerosis and to observe the time points of clinical significance for rosuvastatin treatment. Methods:Our study included two groups,Treatment group,81 patients with carotid atherosclerosis were randomly selected with oral rosuvastatin 10mg/d for 6 months,and Control group,52 subjects with normal carotid artery were enrolled at the same period of time and all participants had low-fat diet.Carotid IMT,serum lipids,high-sensitivity C-reactive protein(hs-CRP)and matrix metalloproteinase-9(MMP-9)were detected at the base line and monthly after the treatment respectively. Results:①Before the treatment,the serum levels of TC,TG,LDL-C,hs-CRP,MMP-9 and carotid IMT were higher in Treatment group than those in Control group,while HDL-C was lower in Treatment group,P0.05 respectively.②In Treatment group,the serum levels of TC,TG,LDL-C,hs-CRP,MMP-9 and carotid IMT were decreased after 6 months of medication than those were before,P0.05 respectively,and HDL-C was increased than it was before,P0.01.③The time points of clinical significance for rosuvastatin in Treatment group as follows:TC,LDL,hsCRP and MMP-9 were decreased after 1 month treatment,TG decreased after 2 months,the HDL was increased after 3 months,and carotid IMT was obviously lower after 6 months of medication,P0.05 respectively. Conclusion:Rosuvastatin could effectively decrease the serum lipids,it has the role of anti-inflammation and anti-carotid atherosclerosis.Carotid IMT could be decreased after 6 months of rosuvastatin medication in patients with carotid atherosclerosis.