ScholarLens Back to search
2009•Chemical ReagentsRequires access

Inhibitory effects of niclosamide derivatives containing polyethylene glycol groups on acetylcholinesterase activity of Oncomelania snail in vitro

Xiaolin Fan

Open publisher page 0 citations

Abstract

The concentrations causing 50% inhibition(IC50) of acetylcholinesterase(AChE) activity by niclosamide derivatives containing polyethylene glycol groups were determined in order to study the effects of niclosamide derivatives on AChE of oncomelania snail in vitro.Test results showed that an increasing drugs concentration would lead to the enhancement of inhibitory effects.With an increasing chain length of polyethylene glycol group linked on niclosamide,the inhibitory effects weakened.

About this research paper

What this paper is about

The concentrations causing 50% inhibition(IC50) of acetylcholinesterase(AChE) activity by niclosamide derivatives containing polyethylene glycol groups were determined in order to study the effects of niclosamide derivatives on AChE of oncomelania snail in vitro.Test results showed that an increasing drugs concentration would lead to the enhancement of inhibitory effects.With an increasing chain length of polyethylene glycol group linked on niclosamide,the inhibitory effects weakened.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The concentrations causing 50% inhibition(IC50) of acetylcholinesterase(AChE) activity by niclosamide derivatives containing polyethylene glycol groups were determined in order to study the effects of niclosamide derivatives on AChE of oncomelania snail in vitro.Test results showed that an increasing drugs concentration would lead to the enhancement of inhibitory effects.With an increasing chain length of polyethylene glycol group linked on niclosamide,the inhibitory effects weakened.

Key concepts: Niclosamide, Chemistry, Polyethylene glycol, Aché, Acetylcholinesterase, Oncomelania, In vitro, Snail

Related papers

Related paper 1Related paper 2
Back to paper searchBrowse research topicsOriginal source
Inhibitory effects of niclosamide derivatives containing polyethylene glycol groups on acetylcholinesterase activity of Oncomelania snail in vitro — Research Paper | ScholarLens