Clinical effect of continuous infusion of midazolam in the treatment of infants' status convulsion

Objective To study the clinical effect and safe of continuous infusion of midazolam in the treatment of infants' status convulsion.Methods 104 cases of infants with status convulsion were randomly assigned into midazolam group or diazepam group:Midazolam 59 cases in Midazolam group were initially given first-dose of midazolam 0.1~0.2 mg·kg-1 intravenously,and after that given maintenance dose of 0.1~0.2 mg·kg-1·h-1,iv,continuously;45 cases in Diazepam group were initiated with a loading dose of 0.2~0.3 mg·kg-1.After initial dose,a maintenance dose of 0.1~0.2 mg·kg-1·h-1 was added.Each medicine was administered with a virtual safe dose according to condition of seizures.The dose and efficacy of midazolam or diazepam were evaluated,the side effect in these infants were observed too.Results The effective rates in the midazolam group and diazepam group were 94.9% and 80%,respectively.There was a significant deviation(χ2=4.65 P0.05),and at the same time,blood pressure and heart rate did not change obviously(P0.05)in the midazolam group.Conclusion Intravenous midazolam infusion may be more effective than diazepam infusion in controlling infants status convulsion,in addition,midazolam has minor influence on circulatorium system.