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2000•Journal of Modern StomatologyRequires access

Effects of tobacco-specific nitrosamines and nicotine on hamster cheek pouch and gastric mucosa

Song Yong-shen

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Abstract

Objective To study the effects of tobacco-specific nitrosamines (TSNA) and nicotine on hamster cheek pouch and gastric mucosa.Methods TSNA and nicotine were used either alone or in combination to paint hamster's cheek mucosa 3 times per week for 6 months.Results Histologic changes,mainly epithelial hyperplasia and hyperkeratosis,were produced in nearly 100% of specimens.Conclusion TSNA is harmful to the hamster's cheek pouch mucosa and is possible to induce premalignant lesions.

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What this paper is about

Objective To study the effects of tobacco-specific nitrosamines (TSNA) and nicotine on hamster cheek pouch and gastric mucosa.Methods TSNA and nicotine were used either alone or in combination to paint hamster's cheek mucosa 3 times per week for 6 months.Results Histologic changes,mainly epithelial hyperplasia and hyperkeratosis,were produced in nearly 100% of specimens.Conclusion TSNA is harmful to the hamster's cheek pouch mucosa and is possible to induce premalignant lesions.

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Available abstract

Objective To study the effects of tobacco-specific nitrosamines (TSNA) and nicotine on hamster cheek pouch and gastric mucosa.Methods TSNA and nicotine were used either alone or in combination to paint hamster's cheek mucosa 3 times per week for 6 months.Results Histologic changes,mainly epithelial hyperplasia and hyperkeratosis,were produced in nearly 100% of specimens.Conclusion TSNA is harmful to the hamster's cheek pouch mucosa and is possible to induce premalignant lesions.

Key concepts: Cheek pouch, Hamster, Gastric mucosa, Nicotine, Cheek, Oral mucosa, Hyperkeratosis, Mesocricetus

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Effects of tobacco-specific nitrosamines and nicotine on hamster cheek pouch and gastric mucosa — Research Paper | ScholarLens