Aplication of Closed Loop of Target Controlled Infusion Feedback with Bispectral Index in Sedation of ICU Patients

Objective To discuss the applicability and value of CLTCI feedback with BIS index in the patients who are required ventilation in ICU.Methods Thrity critical patients undergoing mechanical ventilation in ICU were randomly divided into three groups,and every group included 10 patients.GroupⅠwas the group of propofol for sedation with micro pump infusion.GroupⅡ was the group of propofol with TCI for sedation.GroupⅢ was the group of propofol with CLTCI which target scope of BIS value was setted from 80 to 70 for sedation.MAP,HR,BIS value,Ramsay score,and the average consumption of propopol in each group for 24 hours were recorded.Results After sedation therapy,the MAP of 3 groups were reduced comparing with the basic values,and the difference of MAP was significant in each group(P0.05).The extent of MAP reduction had no significant difference among groups(P0.05).For HR,there was no significant difference comparing with the basic value in each group(P0.05).The correlation was proved between BIS and Ramsay score in each group.For the percent of time of maintaining the patients on condition of ideal sedation,groupⅢ comparing withⅠand Ⅱ,there was a significant difference(P0.05).For the percent of time of BIS within the range from 80 to 70,group Ⅲ comparing withⅠand Ⅱ,there was a significant difference(P0.05).The average consumption of propopol of groupⅢ was less than others(P0.05).Conclusion CLTCI is a better means of sedation comparing with TCI and micro pump infusion,and it can provide ideal level of sedation without inadequate or excessive sedation,keep the relative stability of hemadynamics,and reduce the average consumption of propopol effectively.