Changes of the intercellular spaces of squamous epithelium of lower esophagus in gastroesophageal reflux disease with esomeprazole

Objective To observe the changes of the intercellular spaces of squamous epithelium of lower esophagus in gastroesophageal reflux disease(GERD) with esomeprazole.Methods Measure the DIS of 5 healthy volunteers by random selection to be the normal reference value.Select 6 cases with non-erosive GERD(NERD) and 5 cases with reflux esophagitis(RE) to be objective observation in the treatment group.Biopsies were taken at 3～5 cm above the dentate line after 3 months treatment with esomeprazole to observe and analyze the DIS changes than no-treatment.Results After 3 months threatment,5/6 cases'DIS had been normal in NERD group(83.3%),4/5 cases'DIS had been normal in RE group(80%).The 2 cases'DIS hadn't been normal and their clinical symptoms hadn't been disappear.Conclusion After 3 months threatment with esomeprazole in GERD,the changes of DIS is remarkable,the improvement of the clinical symptoms is remarkable too.