An Analysis of Related Factors to Acute Radiation Pneumonitis in Patients with Lung Cancer

[Purpose] To investigate the related factors to acute radiation pneumonitis in patients with lung cancer after radiotherapy.[Methods] One hundred and seventy one patients with lung cancer after radiotherapy were enrolled.Logistic regression was applied to analyze the relationship between incidence of acute radiation pneumonitis over grade 3 and factors including gender,age,chemotherapy,radiation dose,V5,V20 and mean lung dose(MLD).[Results] Of 171 patients,50 patients(29.3%) occurred acute radiation pneumonitis over grade 3.The univariate analysis showed that patient with smoking,excessive chemotherapy cycles before radiotherapy,concurrent chemoradiotherapy,V540%,V2025%,V2028%,MLD10Gy and MLD13Gy all had a higher incidence rate of acute radiation pneumonitis over grade 3.The multivariate analysis showed that smoking,excessive chemotherapy cycles before radiotherapy,V2028% and MLD13Gy increased the incidence rate of acute radiation pneumonitis over grade 3.[Conclusion] For lung cancer radiotherapy plan designing,not only the suitable physical parameters,but also patient's individual factors including smoking history,chemotherapy history should be considered in order to decrease incidence rate of acute radiation pneumonitis.