Progress on IBV Immune Mechanisms and Immune Prevention and Control

Infectious bronchitis(IB) is an acute,highly contagious viral respiratory disease of chickens caused by infectious bronchitis virus(IBV).IBV circulates in chickens worldwide and induces serious economic consequences in poultry industry.Vaccination is the most efficacious measures to prevent this disease.However,IBV has a lot of serotypes,and its genome evolves continually.This makes the control of IBV more difficult.IBV most commonly affects the respiratory system,genitourinary system and digestive system in chicken with symptoms including dyspnea,egg production drop,nephritis and proventriculitis,etc.IBV is characterized by frequent variations and complex serotypes,which lead to great differences in the clinical manifestations.IB has become one of the most difficult diseases to control.The immune mechanisms of infectious bronchitis virus(IBV) on chicken is one of the hot spots at home and abroad.The traditional vaccine has not been able to protect the immunized chicken group completely.Developing IBV genetic engineering vaccine,from the main immunogenic protein's good expression to the immune strategy's consummation,has become the tendency for preventing IB in the future.