The Significance in Diagnosis and Treatment of Ovarian Cancer with IL-6 as a Tumor Marker

Objective:To investigate the possibility with IL-6 as a new tumor marker for early diagnosis and differential diagnosis of ovarian cancer or benign tumor;to observe the significance of the variation before and after treatment of IL-6;to study the significance of simultaneous determination with IL-6 and CA125 for early diagnosing and monitoring of curative effect of ovarian cancer.Method:The study group was the patients(n=30) with idiopathic epithelial ovarian cancer,the control group was the patients(n=40) with ovarian benign tumor,normal female,endometriosis and other gynecological malignant tumor,serum IL-6 and CA125 levels were determined in the study group and other gynecological malignant tumor group perioperatively and post-chemotherapy from the first to the fourth time,serum IL-6 and CA125 levels were also determined in normal before research,other ovarian benign tumor group and endometriosis group perioperatively,as to investigate the significance in diagnosis and treatment of ovarian cancer with IL-6 as a new tumor marker.Result:Serum IL-6 levels in the study group were significantly higher than those in the control group(P0.01),and serum IL-6 levels were gradually decreased in the study group at postoperation and post-chemotherapy(P0.05);the sensitivity for early diagnosis of ovarian cancer were increased with simultaneous determination with IL-6 and CA125(P0.05).Conclusion:Serum IL-6 levels can be used for early diagnosis and prognostic evaluation of ovarian cancer as a reliable indicator,the early diagnosis rate of ovarian cancer can be increased with simultaneous determination with IL-6 and CA125.