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2006•Zhongguo kangganran hualiao zazhiRequires access

Study on the resistant genes in clinical isolates of Acinetobacter baumannii

XU Yuan-hon

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Abstract

ObjectiveTo study the relationship between antibiotic resistance and resistant gene in clinical isolates of Acinetobacter baumannii.MethodsThe antibiotic resistance was determined by Kirby-Bauer method in 17 strains of A.baumannii.The resistant genes were detected by polymerase chain reaction(PCR).ResultsTwelve strains were identified as multiresistant isolates with presence of bla_(TEM),ampC,aacA4 and mutation of gyrA gene.Of the other five strains,4 carried bla_(TEM) gene,and 2 had gyrA without expression.ConclusionsThe multiple resistance of A.baumannii has close relation to concomitant presence of bla_(TEM),ampC,aacA4 genes and mutation of gyrA gene.

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What this paper is about

ObjectiveTo study the relationship between antibiotic resistance and resistant gene in clinical isolates of Acinetobacter baumannii.MethodsThe antibiotic resistance was determined by Kirby-Bauer method in 17 strains of A.baumannii.The resistant genes were detected by polymerase chain reaction(PCR).ResultsTwelve strains were identified as multiresistant isolates with presence of bla_(TEM),ampC,aacA4 and mutation of gyrA gene.Of the other five strains,4 carried bla_(TEM) gene,and 2 had gyrA without expression.ConclusionsThe multiple resistance of A.baumannii has close relation to concomitant presence of bla_(TEM),ampC,aacA4 genes and mutation of gyrA gene.

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Available abstract

ObjectiveTo study the relationship between antibiotic resistance and resistant gene in clinical isolates of Acinetobacter baumannii.MethodsThe antibiotic resistance was determined by Kirby-Bauer method in 17 strains of A.baumannii.The resistant genes were detected by polymerase chain reaction(PCR).ResultsTwelve strains were identified as multiresistant isolates with presence of bla_(TEM),ampC,aacA4 and mutation of gyrA gene.Of the other five strains,4 carried bla_(TEM) gene,and 2 had gyrA without expression.ConclusionsThe multiple resistance of A.baumannii has close relation to concomitant presence of bla_(TEM),ampC,aacA4 genes and mutation of gyrA gene.

Key concepts: Acinetobacter baumannii, Microbiology, Gene, Biology, Polymerase chain reaction, Acinetobacter, Antibiotics, Bacteria

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