Changes of serum urea nitrogen,creatinine and uric acid levels in pregnant women with gestational diabetes mellitus combined with hypertensive disorder complicating pregnancy

Objective:To analyze the changes of serum urea nitrogen,creatinine and uric acid levels in pregnant women with gestational diabetes mellitus(GDM) combined with hypertensive disorder complicating pregnancy(HDCP),in order to find abnormal indexes early and take preventive measures early.Methods:The changes of serum urea nitrogen,creatinine and uric acid levels during the second trimester of pregnancy in 112 pregnant women with GDM(A group),38 pregnant women with GDM combined with HDCP(B group) and 32 pregnant women with normal 75 g oral glucose tolerance test(OGTT)(NGT group) were observed and compared.Results:Compared with NGT group and A group,FPG,2-hour PG,HbA1C,serum urea nitrogen,creatinine and uric acid in B group increased significantly(P0.01).Compared with NGT group,FPG,2-hour PG and HbA1C in A group increased significantly(P0.01),there was no significant difference in serum urea nitrogen,creatinine and uric acid levels between A group and NGT group(P0.05).Conclusion:When GDM can not be controlled well during pregnancy,and serum urea nitrogen,creatinine and uric acid levels are higher than those of normal pregnant women,preventive measures should be taken to avoid the occurrence of HDCP.