Ovarian malignant lymphoma:a clinicopathologic analysis of 6 cases

Objective To investigate the clinicopathologic features and differential diagnosis of ovarian malignant lymphoma. Methods The medical records,histopathologic features and immunophenotype of ovarian malignant lymphoma were analyzed in six cases.The diagnosis and histological classification were referred to the criteria of the World Health Organization classification for tumours of the hematopoietic and lymphoid tissues(2001). Results The mean age of the 6 patients was 51 years old.The major clinical manifestations were abdominalgia and abdominal mass.Six patients were diagnosed as diffuse large B-cell lymphoma.Tumor cells showed a diffuse growth pattern.The large nuclei were round or oval shape with thick nuclear membrane and clear nucleoli.The tumor cells expressed CD20,CD79a and MUM-1,while CD3,CD43,MPO,CD117,PLAP and TdT were negative. Conclusion Ovarian lymphoma is uncommon.The diagnosis depends on the histologic and immunohistochemical detection and it should be distinguished from granulocytic sarcoma,dysgerminoma and small cell carcinoma.