Clinicopathologic Study of Extranodal Marginal Zone B-cell Lymphoma of Mucosa Associated Lymphoid Tissue Type

Objective To study the clinicopatholgical characteristics of extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue type(MALT-MZL).Methods Analyze clinical status and characteristics of histopathology of 30 cases with MALT-MZL.22 cases were stained for CD20,CD45RO,CD3,CD5,CD10,CD23,bcl-2 and bcl-10,with immunohistochemical techniques.Results The middle old age was predominant in all of the cases (mean 51.2 years),presenting major complaints such as abdominalgia(88.9%).The lesion mucosa would be like ulcer(43,3%),nodositas(50%),and cyri(50%),with poor elasticity(93.3).The tumor cells are marginal zone B cell,monocytoid B cell,more or less small lymphocyte,plasma cell transformed cell.There were lymphoepithelial lesions in 19 cases and follicular colonnization in 14 cases.Among 22 cases,10 showed immunohistochemistry positive CD20 and bcl 2,while CD45RO,CD3,CD5,CD10,CD23 were negative.Sixteen cases showed a positive bcl-10;nuclear expression was positive in 5 and negative in 11 among which 9 expressed cytoplasm. Twelve cases were followed up.Among them 11 were lived,1 accepted chemiotherapy and died after 4 years.Conclusion MALT-MZL is a kind of low grade malingnant lymphoma,having some clinical characteristics.Combination of HE and immunochemistry attribute to the diagnosis and differential diagnosis.