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2006•Medical Journal of National Defending Forces in Northwest ChinaRequires access

Experimental study on hepatocyte apoptosis and expressions of Fas and FasL in alcohol-induced liver injury in rats

LU Xi-chun

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Abstract

Objective:To study the relationship between hepatocyte apoptosis and expression of Fas and FasL in(alcohol-induced) liver injury in rats and their effects on the pathogenesis of alcoholic liver disease(ALD).Methods:The alcohol-induced liver injury model was established in rats.The TUNEL assay was used to examine the hepatocyte apoptosis index,and the Fas FasL expressions were detected by immunohistochemistry.Results: The apoptosis indexes in pathologic model group and control group were(2.03±1.61)% and(0.10±0.21)% respectively(P0.05).The cell numbers of the positive Fas and FasL expressions in pathologic model group and control group were 7.23±1.10 vs 0.58±0.17(P0.05) and 5.14±0.76 vs 0.31±0.25(P0.05),respectively.Conclusion: Chronic and excessive alcohol consumption may cause liver injury in rats,which may induce hepatocyte apoptosis.The hepatocyte apoptosis may be related with the up-regulation of the Fas FasL expressions.

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Objective:To study the relationship between hepatocyte apoptosis and expression of Fas and FasL in(alcohol-induced) liver injury in rats and their effects on the pathogenesis of alcoholic liver disease(ALD).Methods:The alcohol-induced liver injury model was established in rats.The TUNEL assay was used to examine the hepatocyte apoptosis index,and the Fas FasL expressions were detected by immunohistochemistry.Results: The apoptosis indexes in pathologic model group and control group were(2.03±1.61)% and(0.10±0.21)% respectively(P0.05).The cell numbers of the positive Fas and FasL expressions in pathologic model group and control group were 7.23±1.10 vs 0.58±0.17(P0.05) and 5.14±0.76 vs 0.31±0.25(P0.05),respectively.Conclusion: Chronic and excessive alcohol consumption may cause liver injury in rats,which may induce hepatocyte apoptosis.The hepatocyte apoptosis may be related with the up-regulation of the Fas FasL expressions.

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Available abstract

Objective:To study the relationship between hepatocyte apoptosis and expression of Fas and FasL in(alcohol-induced) liver injury in rats and their effects on the pathogenesis of alcoholic liver disease(ALD).Methods:The alcohol-induced liver injury model was established in rats.The TUNEL assay was used to examine the hepatocyte apoptosis index,and the Fas FasL expressions were detected by immunohistochemistry.Results: The apoptosis indexes in pathologic model group and control group were(2.03±1.61)% and(0.10±0.21)% respectively(P0.05).The cell numbers of the positive Fas and FasL expressions in pathologic model group and control group were 7.23±1.10 vs 0.58±0.17(P0.05) and 5.14±0.76 vs 0.31±0.25(P0.05),respectively.Conclusion: Chronic and excessive alcohol consumption may cause liver injury in rats,which may induce hepatocyte apoptosis.The hepatocyte apoptosis may be related with the up-regulation of the Fas FasL expressions.

Key concepts: Fas ligand, Apoptosis, Hepatocyte, TUNEL assay, Pathogenesis, Immunohistochemistry, Liver injury, Medicine

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