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[Dynamic change in interleukin-18 and its relationships with multiple organ dysfunction syndrome].

Jing-Qu Liu, Zhong-jie He, Hongyuan Lin, Yong-ming Yao, Zhi-yong Sheng

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Abstract

OBJECTIVE: To determine interleukin-18 (IL-18) in plasma after trauma, and evaluate its relationship with multiple organ dysfunction syndromes. METHODS: A total of 54 patients were enrolled and divided into low injury seriousness score (L-ISS) and high injury seriousness score (H-ISS) groups. Blood IL-18 levels were determined on admission, day 4, day 7 and day 14 after trauma using enzyme-linked immunoadsorbent assay (ELISA), and the relationship between its level and organ dysfunction was analyzed. RESULTS: Plasma IL-18 concentration was significantly increased on posttrauma day 4 and day 7. Also, plasma IL-18 concentration was significantly higher in patients with organ dysfunction. CONCLUSION: This study suggests that major trauma can lead to a marked elevation of IL-18, which might be associated with organ dysfunction.

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What this paper is about

OBJECTIVE: To determine interleukin-18 (IL-18) in plasma after trauma, and evaluate its relationship with multiple organ dysfunction syndromes. METHODS: A total of 54 patients were enrolled and divided into low injury seriousness score (L-ISS) and high injury seriousness score (H-ISS) groups. Blood IL-18 levels were determined on admission, day 4, day 7 and day 14 after trauma using enzyme-linked immunoadsorbent assay (ELISA), and the relationship between its level and organ dysfunction was analyzed. RESULTS: Plasma IL-18 concentration was significantly increased on posttrauma day 4 and day 7. Also, plasma IL-18 concentration was significantly higher in patients with organ dysfunction. CONCLUSION: This study suggests that major trauma can lead to a marked elevation of IL-18, which might be associated with organ dysfunction.

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Available abstract

OBJECTIVE: To determine interleukin-18 (IL-18) in plasma after trauma, and evaluate its relationship with multiple organ dysfunction syndromes. METHODS: A total of 54 patients were enrolled and divided into low injury seriousness score (L-ISS) and high injury seriousness score (H-ISS) groups. Blood IL-18 levels were determined on admission, day 4, day 7 and day 14 after trauma using enzyme-linked immunoadsorbent assay (ELISA), and the relationship between its level and organ dysfunction was analyzed. RESULTS: Plasma IL-18 concentration was significantly increased on posttrauma day 4 and day 7. Also, plasma IL-18 concentration was significantly higher in patients with organ dysfunction. CONCLUSION: This study suggests that major trauma can lead to a marked elevation of IL-18, which might be associated with organ dysfunction.

Key concepts: Medicine, Organ dysfunction, Multiple organ dysfunction syndrome, Interleukin 6, Seriousness, Internal medicine, Injury Severity Score, Gastroenterology

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[Dynamic change in interleukin-18 and its relationships with multiple organ dysfunction syndrome]. — Research Paper | ScholarLens