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2004•Zhongguo quanke yixueRequires access

The relationship of the dynamical expression of MMP-9 and brain edema in intracerebral hemorrhage rat model

Chunyan Liu

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Abstract

Objective To investigate the expression of MMP-9 in rat brain of intracerebral hemorrhage(ICH),and to study the correlation MMP-9 and brain edema.Methods ICH rat model was made by stereotactic technique,and sham injections served as controls.We measured brain water content,and MMP-9 expression after ICH.Results The brain edema and MMP-9 expression reached the maximum after ICH form 24 h to 72 h.There are marked differences compared with the sham.Conclusion The expression of MMP-9 at higher level and brain edema formation were synchronization at progress.MMP-9 were the key substance which induced the brain edema.

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Objective To investigate the expression of MMP-9 in rat brain of intracerebral hemorrhage(ICH),and to study the correlation MMP-9 and brain edema.Methods ICH rat model was made by stereotactic technique,and sham injections served as controls.We measured brain water content,and MMP-9 expression after ICH.Results The brain edema and MMP-9 expression reached the maximum after ICH form 24 h to 72 h.There are marked differences compared with the sham.Conclusion The expression of MMP-9 at higher level and brain edema formation were synchronization at progress.MMP-9 were the key substance which induced the brain edema.

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Available abstract

Objective To investigate the expression of MMP-9 in rat brain of intracerebral hemorrhage(ICH),and to study the correlation MMP-9 and brain edema.Methods ICH rat model was made by stereotactic technique,and sham injections served as controls.We measured brain water content,and MMP-9 expression after ICH.Results The brain edema and MMP-9 expression reached the maximum after ICH form 24 h to 72 h.There are marked differences compared with the sham.Conclusion The expression of MMP-9 at higher level and brain edema formation were synchronization at progress.MMP-9 were the key substance which induced the brain edema.

Key concepts: Medicine, Brain edema, Intracerebral hemorrhage, Edema, Matrix metalloproteinase, Cerebral edema, Rat model, Pathology

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