CCR5 expression in peripheral blood mononuclear cells of patients with hepatitis B

Objective To investigate the role of CC chemokine receptor 5(CCR5) in the immunological pathogenesis of hepatitis B(HB).?Methods The expression levels of CCR5 in peripheral blood mononuclear cell(PBMC) were assayed by flow cytometry before and after PHA-induced cultivation in 20 HB patients and 20 normal controls(NC).?Results Before cultivation,there was no discrepancy in CCR5 level between NC and HB(P0.05).After cultivation,CCR5 was obviously lowered in NC group(P0.05),but insignificantly in HB group(P0.05),with the slightly lowering CCR5 levels in an order as AHBCHBLC.It was also noticed that the CCR5 level was lower in the HB patients positive for HBV duplicating markers than that in those who were negative(P0.05).?Conclusion CCR5 expression level in PMBC may be related to the outcome of HB,and higher levels of CCR5 suggest relatively favorable prognosis and limit HBV replication.