Effect of hydroprednisone on neuromuscular blockade of rocuronium in female patients during general anesthesia

Objective To investigate the effect of hydroprednisone on onset time and recovery time of rocuronium in female patients during general anesthesia.Methods Forty ASA ⅠorⅡfemale patients,aged 18-65yr,body mass index 18.5-25kg /m 2,scheduled for elective thyroid or breast surgery were randomly divided into two groups with 20each:hydroprednisone group(group H) and control group(group C).30mg of hydroprednisone was injected in patients of group H 50min before anesthesia induction.Same anesthesia was induced in both groups.The train-of-four(TOF) ratio at the adductor pollicis muscle was measured by TOF-watch.The following parameters were measured including onset time,duration of recovery to a TOF rate of 25%,75% and from 25% to 75%.Results The onset time in group H [(129.30±28.57)s] was significantly longer than that in group C [(83.55±17.90)] s(P0.05).The duration to a TOF rate of 25% and 75% were significantly reduced in group H [(40.95±2.89) and(50.65±4.63) min],respectively compared with that in group C [(49.55±5.81) and(62.50±5.19) min](P 0.05).The recovery time of TOF ratio from 25%to 75%in group H [(9.70±2.83) min] is shorter than that in group C [(12.95±4.65) min(P0.05).Conclusion Hydroprednisone may result in a longer onset time,but shorter recovery time of rocuronium in female patients during general anesthesia.