Clinical significance of determination of rheumatoid factor by immunoturibidimetric assay and latex particle agglutination test

Objective:To investigate the significance of rheumatoid factor determination by using different methods.Methods:The level of serum rheumatoid factor was detected by the immunoturibidimetric assay and latex particle agglutination test in 35 cases of rheumatoid arthritis,43 cases of other diseases without rheumatical arthritis and 20 healthy controls.Results:The positive percent of the rheumatoid arithritis group,the group of other diseases and the control group was 56.9%,23.3% and 0,respectively by using the immunoturibidimetric assay;and 74.3%,46.5%and 20.0%,respectively by using latex particle agglutination test.The diagnostic efficiency by using the immunoturibidimetric assay and latex paiticle agglutination test was 74.5% and 66.3%,respectively.Conclusion:Only IgM-RF can be detected by the immunoturibidimetric assay and latex particle agglutination test.Rheumatiod factor determination by the latex particle agglutination is more sensitive than that by the immunoturibidimetric assay,with lower specificity and lower diagnosis efficiency of the latex particle agglutination test compared with the immunoturibidimetric assay.