Effect of simvastatin on acute coronary syndrome complicated with atrial fibrillation

Objective: To investigate the effect of simvastatin on acute coronary syndrome complicated with atrial fibrillation.Methods: A total of 112 cases with acute coronary syndrome complicated with atrial fibrillation were randomly divided into treatment group(60 cases) and control group(52 cases).Besides conventional treatment,simvastatin was used at 40 mg/d for 4 weeks,then 20 mg/d.Therapy of simvastatin was irregular in control group with total course less than 8 weeks,and the total course was 12 months.Hepal and renal function,high senstive C-reaction protein,blood lipid,reoccurrence of paroxysmal atrial fibrillation,incidence of sustained or permanent atrial fibrillation and status of cardiovascular diseases.Results: There was insignificant difference in blood lipid and C-reactive protein before and after treatment in control group(P0.05).After treatment,the levels of total cholesterol,low-density cholesterol and C-reactive protein were significantly decreased(P0.05),and high-density lipoprotein was significantly increased(P0.05) in treatment group.6 cases(10%) had reoccurrence of paroxysmal atri-al fibrillation or had paroxysmal transforming into sustained or permanent one in treatment group,which was significantly lower than control group(17/52,36.5%)(P0.05).And 8 cases had cardiovascular problem,significantly lower than control group(22/52,42.3%)(P0.05).Conclusion: Simvastatin can regulate blood lipid,anti-atrial fibrillation,and decrease the incidence of cardiovascular diseases.