Evaluation of efficacy and safety of 2% Liranaftate cream in the treatment of tinea pedis and tinea corporis & cruris

Objective To compare the efficacy and safety of liranaftate 2% cream and bifonazole 1% cream in the treatment of tinea pedis and tinea corporis cruris.Methods A multi-center,double-blind,randomized controlled trial was conducted.Liranaftate 2% cream and bifonazole 1% cream were applied in the trial and control group respectively once daily for 4 weeks to tinea pedis and for 2 weeks to tinea corporis cruris.Results Seventy-one cases in the trial group and 70 cases in control group were evaluated for tinea pedis;70 cases in the trial group and 69 cases in the control group were evaluated for tinea corporis cruris.The clinical effective rates for tinea pedis at week 4 were 97.2% in the trial group and 92.9% in control group;and 100% versus 98.6% at week 6 respectively.Mycological cure rates for tinea pedis at week 4 were 93.0% in the trial group and 94.3% in control group;and 94.4% versus 92.9% at week 6 respectively.The total effective rates for tinea pedis at week 4 were 90.1% in the trial group and 88.6% in control group;and 94.4% versus 92.9% at week 6 respectively.The clinical effective rates for tinea corporis cruris at week 2 were 97.1% in the trial group and 95.7% in control group;and 97.1% versus 94.2% at week 4 respectively.Mycological cure rates for tinea corporis cruris at week 2 were 94.3% in the trial group and 95.7% in control group;and 97.1% versus 97.1% at week 4 respectively.The total effective rates for tinea corporis cruris at week 2 were 92.9% in the trial group and 91.3% in control group;and 95.7% versus 94.2% at week 4 respectively.Treatment-related adverse events consisted of local irritation,occurred in 1.4% of patients in the control group.The effcacy and safety of liranaftate 2% cream in the treatment of tinea pedis and tinea corporis cruris are similar to that of bifonazole 1% cream(P0.05).Conclusion This study suggest that liranaftate 2% cream was effective and safe in the treatment of tinea pedis and tinea corporis cruris.