Clinical Observation of 65 Cases Treated with Naftifine Hydrochloride and Ketoconazole Cream Combined with Adapalene in Pityriasis Versicolor

Objective To observe the therapeutic effect and the safety of combination naftifine hydrochloride and ketoconazole cream with adapalene gel in the treatment of pityriasis versicolor. Methods Sixty-five patientients suffering with pityriasis versicolor were divided randomly into two groups. The treatment group was topically applied by naftifine hydrochloride and ketoconazole cream and adapalene gel once daily,respectively. The control group was treated only with naftifine hydrochloride and ketoconazole cream twice daily,all the patients were treated for two weeks. The clinical efficacy and fungi clearance rates were compared between the two groups at the end of treatment 2 weeks after the end of the treatment. Results At the end of treatment and 2 weeks after the end of the treatment,the clinical efficacy rates were 84. 85% and 96. 97% in treatment group,62. 50% and 75. 00% in control group,respectively. The clinical efficacy rates of the treatment group were all higher than those of the control group,the difference was statistically significant( P 0. 05). No severe incidence of adverse reaction was found in both groups. Conclusion Favorable curative effect was observed in the treatment with the combination of naftifine hydrochloride and ketoconazole cream and adapalene gel in the patients with pityriasis versicolor. There was synergistic action in the treatment with adapalene gel and naftifine hydrochloride and ketoconazole cream in pityriasis versicolor.