ScholarLens Back to search
2012•Zhonghua putong waike zazhiRequires access

Importance of thymidine phosphorylase in colorectal cancer investigation

Jimin Zhang

Open publisher page 0 citations

Abstract

Investigations reveal thymidine phosphorylase has the effects of promoting tumor angiogenesis and inhibiting cell apoptosis,and is closely related to the prognosis and outcome of the cancer patients.Meanwhile,it is also the key converting enzyme for the prodrugs of 5-fluorouracil such as 5'-deoxy-5-fluorouridine.This paper reviews the advances in the investigation of thymidine phosphorylase,including its expression and function in colorectal cancer tissue,converting effect on 5'-deoxy-5-fluorouridine and therapeutic potential.

About this research paper

What this paper is about

Investigations reveal thymidine phosphorylase has the effects of promoting tumor angiogenesis and inhibiting cell apoptosis,and is closely related to the prognosis and outcome of the cancer patients.Meanwhile,it is also the key converting enzyme for the prodrugs of 5-fluorouracil such as 5'-deoxy-5-fluorouridine.This paper reviews the advances in the investigation of thymidine phosphorylase,including its expression and function in colorectal cancer tissue,converting effect on 5'-deoxy-5-fluorouridine and therapeutic potential.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Investigations reveal thymidine phosphorylase has the effects of promoting tumor angiogenesis and inhibiting cell apoptosis,and is closely related to the prognosis and outcome of the cancer patients.Meanwhile,it is also the key converting enzyme for the prodrugs of 5-fluorouracil such as 5'-deoxy-5-fluorouridine.This paper reviews the advances in the investigation of thymidine phosphorylase,including its expression and function in colorectal cancer tissue,converting effect on 5'-deoxy-5-fluorouridine and therapeutic potential.

Key concepts: Thymidine phosphorylase, Prodrug, Medicine, Thymidine, Colorectal cancer, Angiogenesis, Cancer research, Enzyme

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Importance of thymidine phosphorylase in colorectal cancer investigation — Research Paper | ScholarLens