Effect of a long-term administering of low dosage La(NO_3)_3 on insulin in serum and hepatocyte glycogen in rat

Objective:To investigate the long-term effects of low dosage La(NO3)3 on insulin and blood glucose in serum and hepatocyte glycogen in rat.Methods:Levels of Insulin and blood glucose and hepatocyte glycogen in rat were measured by radiommunoassay and microscopy image analysis system after administrated with La(NO3)3(10.0 mg/kg、 2.0 mg/kg、 0.2 mg/kg、 0.1 mg/kg)for six and seven months.Results:Having taken La(NO3)3 for 6 months,insulin levels in the 10.0 mg/kg group were reduced,blood glucose and hepatocyte glycogen levels in the 10.0 mg/kg group were increased,both in the sera of female and male rats;insulin levels、 blood glucose levels and hepatocyte glycogen levels in the 0.1 mg/kg、 0.2 mg/kg、 2.0mg/kg group,low dose treated groups was increased and later was reduced in the sera of the male.After fed by normal chow without La(NO3)3 for one month,the levels of insulin、 blood glucose and hepatocyte glycogen returned to normal again.Conclusion:A long-term low dosage La(NO3)3 could change insulin、 blood glucose and hepatocyte glycogen levels.Insulin、 blood glucose and hepatocyte glycogen levels could back to normal levels after a short time of feeding without La.La(NO3)3.In concentration of 0.2 mg/kg and 0.1 mg/kg,it had the capacity to increase the levels of insulin、 blood glucose and hepatocyte glycogen.