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2007•Zhongguo jiceng yiyaoRequires access

Rat retinal morphological changes after optic nerve crush

Qiao-yan Long

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Abstract

Objective To observe the morphological change of retina after optic nerve crush in adult rats. Methods The models of optic nerve crush in rats were made.The change of retinas in different time(1,3,7,15, 30d respectively)after injury were observed by light microscope.Results The number of retinal ganglion cells (RGCs)was significantly reduced in the partial lesion of optic nerve crush compared with normal optic nerves with- out injury.Conclusion A pair of cross-action forceps with pressure of 40g used to clip rat optic nerves to create ONI animal model was possible,and could be used in ONI recovery response.

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What this paper is about

Objective To observe the morphological change of retina after optic nerve crush in adult rats. Methods The models of optic nerve crush in rats were made.The change of retinas in different time(1,3,7,15, 30d respectively)after injury were observed by light microscope.Results The number of retinal ganglion cells (RGCs)was significantly reduced in the partial lesion of optic nerve crush compared with normal optic nerves with- out injury.Conclusion A pair of cross-action forceps with pressure of 40g used to clip rat optic nerves to create ONI animal model was possible,and could be used in ONI recovery response.

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Available abstract

Objective To observe the morphological change of retina after optic nerve crush in adult rats. Methods The models of optic nerve crush in rats were made.The change of retinas in different time(1,3,7,15, 30d respectively)after injury were observed by light microscope.Results The number of retinal ganglion cells (RGCs)was significantly reduced in the partial lesion of optic nerve crush compared with normal optic nerves with- out injury.Conclusion A pair of cross-action forceps with pressure of 40g used to clip rat optic nerves to create ONI animal model was possible,and could be used in ONI recovery response.

Key concepts: Optic nerve, Crush injury, Medicine, Retina, Lesion, Anatomy, Retinal, Ophthalmology

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