Drug resistance of common pathogenic bacteria in elderly patients with urinary tract infection

Objective The aim of the study is to investigate the drug resistance of common pathogenic bacteria in elderly patients with urinary tract infection,and to guide the clinical application of antibacterial agents.Methods Vitek-Ams System and Kirby-Bauer method were adopted to perform bacterial culture for samples from 267 elderly patients with urinary tract infection and to analyze the drug resistance to a serial of antibiotics.Results A total of 304 strains of pathogenic bacteria were isolated,among which 66.1% were gram negative bacilli(201/304),including Escherichia coli(45.1%,137/304),Pseudomonas aeruginosa(8.2%,25/304),Klebsiella pneumoniae(6.3%,19/304),and Bacillus proteus(4.3%,13/304).The isolated gram negative bacilli were high resistant to cephalosporins III perhaps due to the increase of ESBLs-producing strains.Imipenem was still the most effective drug to treat the infection of gram negative bacilli.The detected rate of gram positive cocci account for 23.0%(70/304);and vancomycin was still the favorable antibiotic to treat the infection of gram positive cocci.The detected rate of fungi was 10.9%(33/304),100% sensitive to amphotericin B.Conclusion The drug resistance of common pathogenic bacteria is serious in elderly patients with urinary tract infection.Continuous monitoring of drug resistance plays an important role in the rational use of antibiotics,enhancement of therapeutic effect and reduction of drug-resistant strains.