Establishment of a Nude Mouse Model of Human Keloid with Epidermis

Objective To establish an ideal animal model for the human keloid in nude mice, and provide an important tool for the experimental and clinical studies of keloid. Methods Pieces of keloids ( 8 mm × 5 mm × 3 mm ) with epidermis or without epidermis were implanted into subcutaneous pockets of nude mice and carried for varying times up to 8 weeks. The persistence time and the change of volume were observed and the histology changes were observed by HE straining. The volume measurements were analyzed by t test. Results The volume of pieces of keloids with epidermis were more large and longer compared to the pieces of keloids without epidermis (p0.05) in the period of 2～8 weeks. The pieces of keloids with epidermis were similar to the human keloids in histology at the 8 weeks. Conclusions The keloid model of human keloid with epidermis is an easily established model, are similar to human keloids both in gross appearance and histology. So this model is an ideal one for the studies of human keloids.