CHANGES AND CLINICAL SIGNIFICANCE OF ERYTHROCYTE SEDIMENTATION RATE AND C-REACTION PROTEIN IN CHILDREN WITH KAWASAKI DISEASE

Objective To assess the changes and significance of erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) in children with Kawasaki disease(KD). Methods Sixty children with KD treated from January,2000 to December,2006 were detected for ESR and CRP before and four weeks after treatment,the changes of ESR and CRP and their relationship with cardiovascular damage were analyzed. Results Before treatment,43 children(71.7%) had ESR value higher than 40 mm/1 h,33(55%) had CRP higher than 30 mg/L.After treatment,there were five children(8.3%) whose ESR still higher than 40 mm/1 h;the ESR of the children with high CK-MB and dilated coronary artery was significantly higher than children with normal CK-MB and normal coronary artery(z=3.225-6.452,P0.01).Taking ESR 40 mm/1 h and CRP 30 mg/L as dividing line,all those with ESR and CRP values lower than the dividing line had dilated coronary artery(100%),only 41.7% of the children with ESR and CRP values lower than 8.3% had high CK-MB. Conclusion The changes of ESR and CRP were closely associated with cardiovascular injury in KD children.