Effects of fluvastatin on serum soluble cell adhesion molecule in patients with heart failure

Objective:To observe the effects of short-term treatment of fluvastatin on serum soluble intercellular adhesion molecule-1(sICAM-1),soluble vascular cell adhesion molecule-1(sVCAM-1),soluble E-selectin(sE-selectin),soluble P-selectin(sP-selectin)and soluble L-selectin(sL-selectin)in patients with congestive heart failure(CHF),and investigate the effects of fluvastatin on the treatment of congestive heart failure.Methods:70 CHF patients were randomly divided into conventional treatment group and intervention group(fluvastatin group).normal control group has 20 cases.using enzyme-linked immunosorbent assay(ELISA)measure levels of serum sICAM-1,sVCAM-1,sE-Selectin,sP-selectin and sL-selectin before and after treatment.Results:Serum soluble cell adhesion molecules(sCAM)levels in patients with heart function class Ⅳ was significantly higher than patients with heart function class Ⅱ and Ⅲ,and the comparison between heart function classⅡ and Ⅲ was not significant,soluble cell adhesion molecules(sCAM)levels of patients with the heart function classⅡ-Ⅳ have an average increase than normal control Group(P0.05 or P0.01).Serum sCAM levels of two groups have significant decrease after treatment(P0.05 or P0.01),compare intervention group with the conventional treatment group,only sVCAM-1 and sE-selectin levels decreased significantly(P0.05),while the other inter-group comparison of serum sCAM levels has no statistical significant(P0.05).Conclusion:The serum sCAM levels of CHF patients were related to the classification of cardiac function,on the basis of conventional treatment together with short-term fluvastatin treatment can not further reduce the total serum sCAM level,so consider effects of taking statin drugs to inflammatory factors may be related to the use of dose,time and the use of population,long-term effect depend on long-term and large samples to be studied further.