The role of quorum sensing systems in the pathogenesis of Pseudomonas aeruginosa infection in vivo

Pseudomonas aeruginosa is an opportunistic bacteria that causes a variety of infections.The cell-density-dependent signaling mechanism called quorum sensing systems plays an important role in several such infections as corneal,lung and burn wound infectiongs.Besides,the quorum sensing system contribute to the ability of Pseudomonas aeruginosa to form biofilms.There are several studies giving credence to the idea that quorum sensing system accomplish their effect by controlling the production of different virulence factors of Pseudomonas aeruginosa and by manipulating the host immune response.