Effect of ischemic preconditioning on lung ischemia reperfusion injury

Objective: To investigate the protective effect of ischemic preconditioning on ischemia/reperfusion(I/R) induced lung injury. Methods: Animal models the ischemic preconditioning was used on animal moclels . Thirty rabbits were divided into three groups: control group (C, n=10), ischemia/reperfusion group(I/R, n=10), ischemic preconditioning group(IP, n=10). Lung injury was assessed by Arterial oxygen tension (PaO\-2), Wet to dry weight ratio (W/D), morphological changes of lung, activities of superoxide dismutase (SOD) and myleoperoxidase (MPO) and level of malondialdehyde (MDA). Results: In I/R group, PaO\-2 descended constantly, especially within 30 minutes after reperfusion. PaO\-2 and the activity of SOD in serum and lung tissue of IP group were significantly higher than those of I/R group (P0.01). W/D and the content of MDA of IP group was significantly lower than those of I/R group (P0.01). The activity of MPO of IP group was significantly lower than those of I/R group (P0.05). Conclusions: Our data showed that IP of lung may have a protective effect against I/R injury by abating capillary permeability, enhancing anti-free-radical ability of organism.