The Renoprotection of Valsartan on Diabetic Nephropathy

Objective:To observe the effect of angiotensin Ⅱ 1 type receptor antagonists(AT 1Ra) Valsartan on the early diabetic nephropathy with microalbuminuria. Methods:40 cases of type 2 diabetes mellitus(DM) without hypertension(24h urine albumine excretion rate(UAER):20～200μg/min) were selected. The changes of mean arterial pressure(MAP), 24h UAER, creatinine clearance(Ccr) were compared before and after the administration of valsartan(80ng/d) for 12 weeks without changing the previous management of DM. Results:No changes of the above indices were observed in the control group. In valsartan group, 24h UAER decreased from 81.9(45～120)μg/min to 62.4(28～89)μg/min( P 0.05). No significant changes were observed in other indices. The therapeutic effect was not related to the change of blood pressure. Conclusion: AT 1Ra valsartan can reduce the albuminuria of early diabetic nephropathy. The effect of renopretection in not soly dependent on the lowering blood pressure levels.Other mechanism may be involved.