Correlational Research on the Expression of Matrix Metalloproteinase-2, Metalloproteinase-9 of Cerebral Astrocytoma and Peritumorous Edema

Objective To investigate the correlation between the expression of matrix metalloproteinase 2(MMPs-2) and matrix metalloproteinase 9(MMPs-9) of cerebral astrocytoma and peritumoral edema, providing a scientific basis for the proper tumor diagnosis and clinical treatment. Methods In 68 cases of astrocytoma tissues, anti-MMPs-2 antibody and anti-MMPs-9 antibody were marked and analysis via Immunohistochemical staining, while tumor peritumoral edema were observed with analysis via magnetic resonance imaging, to make correlation analysis between the expression of matrix metalloproteinases and peritumoral edema index by data analysis software. Results With the increasing malignancy degree of tumor, the expression of matrix metalloproteinases 2,9 in astrocytoma was increasing. In addition, the expression level of astrocytoma matrix metalloproteinase 2,9 and peritumoral edema was positive correlation(p0.05). With the increasing of expression levels of MMPs-2 and MMPs-9,the greater the scope of peritumoral edema and the greater malignant astrocytoma were. Conclusion Astrocytoma expression of matrix metalloproteinases 2,9 was close relationship with peritumoral edema, a positive correlation. the expression level of MMPs-2 and MMPs-9 was related with the rate of tumor growth and invasion, which had important reference significancethe for the prediton of cerebral astrocytoma invasion, the malignancy degree and the treatment.