Synthesis of 2,4,4′,6-tetramethoxydeoxybenzoin

2,4,4′,6-tetramethoxydeoxybenzoin was prepared from 1,3,5-trimethoxybenzene and 2-(4-methoxy phenyl)acetonitrile as materials,and toluene as solvent instead of diethyl ether.Through Hoesch reaction,the target compound 2,4,4′,6-tetramethoxydeoxybenzoin was got.It was characterized by H1NMR.Because of the protective effect of ether bond,the side reactions were inhibited,and the yield of Hoesch reaction was reached to 82.2% after the synthetic method was improved.Reaction time and the amount of solvent on the yield were researched.Optimization of reaction conditions were reaction time 28h and the amount of solvent 150mL,under the other conditions constant.