Clinical Values of Combined Detection of Ultrasound and Serum Beta-hC G in Evaluating Early Pregnancy of Unknown Location Outcome

Objective To investigate the clinical values of combined detection of ultrasound and serum beta human chorionic gonadotropin( beta- h CG) examination in predicting early pregnancy of unknown location( PUL) outcome. Methods109 cases of PUL admitted to the First Affiliated Hospital of Xinjiang Medical University from May 2011 to May 2013 were selected. All the cases had a history of menopause for 4 to 6 weeks,and had positive outcome of urine or serum beta- h CG examination. The first ultrasound examination after admission showed no typical fertilized egg both inside and outside the uterus,and then the beta- h CG examination was performed on the day of admission and 48 h later. All the cases were divided into IUP group( 31cases),IUPM group( 21 cases) and EP group( 57 cases). The 48 h growth of endometrial thickness,pregnancy luteal blood flow distribution and serum beta- h CG were compared between the three groups. Results The ultrasound examination showed that the IUP group had thicker endometrial thickness 〔( 1. 25 ± 0. 22) cm〕compared with the IUPM group 〔( 0. 78 ± 0. 30) cm〕and EP group 〔( 0. 75 ± 0. 31) cm〕( P 0. 001),while the endometrial thickness between the IUPM group and EP group showed no statistically significant difference( P 0. 05). IUPM group and EP group blood signal loss rate were higher than that of IUP group,EP group was higher than in IUPM group( P 0. 05). The beta- h CG 48 h growth value in the IUP group 〔( 2 569± 1 033) mmol / L〕was higher than the IUPM group 〔( 234 ± 264) mmol / L〕and EP group 〔( 456 ± 571) mmol / L〕,and the EP group was also higher than the IUPM group( P 0. 05). The proportion of beta- h CG 48 h growth 60% in IUP group〔93. 5%( 29 /31) 〕was higher than the IUPM group〔14. 3%( 3 /21) 〕and EP group〔33. 3%( 19 /57) 〕,and the EP group was also higher than the IUPM group( P 0. 017). Conclusion Ultrasonic detection of endometrial thickness,pregnancy luteal blood flow signal loss and serum beta- h CG 48 h growth rate has certain clinical value in evaluating the PUL pregnancy outcome.