Effect of the change of hippocampal pyramidal cell on abilities of learning and memory of vascular dementia rats

Objective To study effects of hippocampal pyramidal cell changes on learning and memory abilities in vascular dementia rats.Methods The rats were divided into control and operation section.The vascular dementia model was reproduced in the operation group.Abilities of learning and memory of two section rats were tested via the Morris water maze after 30 days.HE staining was used to observe the number of hippocampal pyramidal cell of hippocampus.Results Abilities of learning and memory of rats and the number of hippocampal pyramidal cell of the hippocampus were more significantly decreased in operation section.Conclusions The number of hippocampal pyramidal cell are decreased and the abilities of learning and memory are descent in vascular dementia rats.