Clinical and pathological study of lamivudine in treatment of chronic hepatitis

AIM: To study the indexes of the HBV in the serum and the changes of liver tissues pathological histology on the patients with chronic hepatitis B before and after treatment with lamivudine. METHODS: Twenty patients (F 14, M 6; age 33 a± s 4 a) with chronic hepatitis [HBV DNA(+),ALT40 U·L -1 ,SB50 μmol·L -1 ] were treated with lamivudine [100 mg, qd×1 a], ALT, HBV DNA, HBeAg in the serum were detected, and the changes of the liver tissue were examined with pathological methods pre and post therapy. RESULTS: After treatment with lamivudine, of the patients with chronic hepatitis B; 20 patients (100%) ALT were decreased, 18 patients (90%) HBV DNA were got negative express; 17 patients (85%) were remarkably reduced in the inflammatory activity of the liver tissues, the results were significantly difference ( P 0.05); 2 patietns (10%) weren't remarkably reduced in the liver tissues fibrosis activity, 4 patients (20%) HBeAg were got negative express. But the results weren't significantly differene ( P 0.05) . CONCLUSION: Lamivudine may improve the liver function, and the HBV DNA gotten negative, and reduce the inflammatory activity. But it may not made HBeAg gotten negative and reduce the liver tissues fibrosis activity of liver tissues for patients with chronic hepatitis B.