Clinical analysis of buprenorphine and ketamine used in postoperation

OBJECTIVE To compare the analgesic effect and the adverse reactions of buprenorphine and ketamine used in patient-controlled intravenous analgesia (PCEA). METHODS The experimental objects were 60 cases of patients who received the lower abdomen optional surgery under Epidural anesthesia, (ASA Ⅰ-Ⅱ) and using the random and double-blind method they were divided into buprenorphine + droperidol (group A), buprenorphine + droperidol + bupivacaine (group B),and ketamine +droperidol + bupivacaine (group C). The additional number within 0-48 hours, visual analog score (VAS), sedation score (Ramsay score), the recovery time of intestinal function and some adverse reactions such as nausea and vomiting were observed. RESULTS The additional number in each period, VAS and Ramsay score were significantly different among Group A ,B and C (P0.05); recovery time of intestinal function between Group A and B, C had a significant difference (P0.05);and in the aspects of the incidence rate of nausea and vomiting, itch of skin, and urinary retention, there was also a significant difference among each group (P0.01). CONCLUSION The analgesic effect of PCEA under local compound anesthetics of buprenorphine and ketamine is certain ; and the ketamine group shows a clear superiority in the aspects of reducing the incidence rate of nausea and vomiting, itch of skin, and urinary retention.