Detection and significance of IL-6 and IL-17 in the placenta and blood in normal pregnancies and preeclampsia

Objective To study and compare the levels of interleukin-6 and interleukin-17 in serum and placenta of women with preeclampsia and normotensive pregnancy.Methods Thirty patients with preeclampsia,and 30 normotensive controls were recruited in this study.The concentrations of IL-6 and IL-17 in serum were measured by enzyme-linked immunosorbent assay(ELISA),and their expressions in the placental specimens were detected by immunohistochemistry.Results There were no statistical differences in maternal age and gestational age between control and preeclampsia group.The neonatal weight in preeclampsia group were significantly lower than those in normal group(P0.01).The mean concentrations of serum IL-6 and IL-17 in preeclamptic subjects were increased significantly as compared with those in healthy control pregnancy(P 0.01).The levels of IL-6 was significantly lower(P0.05) in preeclamptic group,whereas the levels of IL-17 showed no significantly differences between two groups(P0.05).Conclusion The inflammatory factors such as IL-6 and IL-17 may play important roles in the pathogenesis of preeclampsia.