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2011•Zhongguo quanke yixueRequires access

Study on Ursodeoxycholic Acid in Treatment of Primary Sclerosing Cholangitis

Zhang Li-l

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Abstract

Primary sclerosing cholangitis(PSC) is an unexplained cholestatic liver disease,and genetic predisposition and environmental factors are possibly responsible for it.Ursodeoxycholic acid(UDCA)is beneficial for cholestatic liver diseases.In primary sclerosing cholangitis(PSC),evidences show that high doses(±20 mg/kg)of UDCA may be more effective than average doses.This article reports on the clinical effect of UDCA in the treatment of PSC with analysis based on literature.

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What this paper is about

Primary sclerosing cholangitis(PSC) is an unexplained cholestatic liver disease,and genetic predisposition and environmental factors are possibly responsible for it.Ursodeoxycholic acid(UDCA)is beneficial for cholestatic liver diseases.In primary sclerosing cholangitis(PSC),evidences show that high doses(±20 mg/kg)of UDCA may be more effective than average doses.This article reports on the clinical effect of UDCA in the treatment of PSC with analysis based on literature.

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Available abstract

Primary sclerosing cholangitis(PSC) is an unexplained cholestatic liver disease,and genetic predisposition and environmental factors are possibly responsible for it.Ursodeoxycholic acid(UDCA)is beneficial for cholestatic liver diseases.In primary sclerosing cholangitis(PSC),evidences show that high doses(±20 mg/kg)of UDCA may be more effective than average doses.This article reports on the clinical effect of UDCA in the treatment of PSC with analysis based on literature.

Key concepts: Ursodeoxycholic acid, Medicine, Primary sclerosing cholangitis, Gastroenterology, Internal medicine, Genetic predisposition, Disease

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