STUDY OF THE RELATIONSHIP OF VASCULAR ENDOTHELIAL CELL INJURY AND MINIMAL PROTEIN OF URINARY AND DIABETIC RETINOPATHY

[Objective]To investigate the levels of von willebrand factor:antigen(vWF:Ag),urinary albumin excretion rate(UAER)and urinary transferring(UTRF)in different stages of DR and their implication.[Methods]129 cases with type 2 diabetes patients were divided into three groups:no diabetic retinopathy group(NDR)71 cases,background diabetic retinopathy group(BDR)39 and proliferative diabetic retinopathy group(PDR)19. UAER and UTRF were measured by rate nephelometry method,vWF:Ag was measured by ELISA.[Results]The serum levels of vWF:Ag,UAER and UTRF in patients with NDR,BDR and PDR were higher than those in control group(P﹤0.01). Between UAER and UTRF,there was a significant difference(P﹤0.01),UTRF was higher than UAER.[Conclusion]Detection of vWF:Ag,UAER and UTRF is very important for early discovery of diabetic retinopathy.