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Study on Mechnism of Antithrombotic Effect of Veratrum Nigrum L.var.Ussurience Nakai Alkaloids

Guozhu Han

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Abstract

Objective To study the mechanism of antithrombotic effect of Veratrum nigrum L. var. ussurience Nakai alkaloids (VnA). Methods Blood stasis models were made and treated with VnA intravenously. The blood samples were collected and tested for platelet aggregation, concentrations of plasma TXA2 and PGI2. Results In comparison with control blood stasis model, V nA treatment significantly inhibited platelet aggregation, decreased plasma TXA2, and increased plasma PGI2. Conclusion VnA increased the ratio of PGI2 and TXA2, thereby inhibiting platelet aggregation.

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What this paper is about

Objective To study the mechanism of antithrombotic effect of Veratrum nigrum L. var. ussurience Nakai alkaloids (VnA). Methods Blood stasis models were made and treated with VnA intravenously. The blood samples were collected and tested for platelet aggregation, concentrations of plasma TXA2 and PGI2. Results In comparison with control blood stasis model, V nA treatment significantly inhibited platelet aggregation, decreased plasma TXA2, and increased plasma PGI2. Conclusion VnA increased the ratio of PGI2 and TXA2, thereby inhibiting platelet aggregation.

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Available abstract

Objective To study the mechanism of antithrombotic effect of Veratrum nigrum L. var. ussurience Nakai alkaloids (VnA). Methods Blood stasis models were made and treated with VnA intravenously. The blood samples were collected and tested for platelet aggregation, concentrations of plasma TXA2 and PGI2. Results In comparison with control blood stasis model, V nA treatment significantly inhibited platelet aggregation, decreased plasma TXA2, and increased plasma PGI2. Conclusion VnA increased the ratio of PGI2 and TXA2, thereby inhibiting platelet aggregation.

Key concepts: Antithrombotic, Medicine, Blood stasis, Platelet aggregation, Platelet, Pharmacology, Traditional medicine, Internal medicine

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