Study advance to fetal sudden death in the late trimester in intrahepatic cholestasis of pregnancy

Fetal sudden death in the late trimester in intrahepatic cholestasis of pregnancy(ICP) is hard to anticipate and monitor,therefore with high risk.It's mechanism is still unkown.The mian research direction nowadays is the influence to the placenta and the damnification to the fetal because of the high serum bile acid level in the pregnant woman and fetal.Especailly a series of researches on the bile acid impairing cardiomyocyte function have proved the cytotoxity of bile acids to the fetal heart is the vital factor that leads the sudden death of fetal.