Clinicopathological Characteristics Analysis of Immuloglobulin A Nephropathy Presented with Isolated Hematuria in Children

Objective To study the clinicopathological characteristics of immuloglobulin A nephropathy(IgAN)presented with isolated hematuria in children,as well as the necessity of renal biopsy.Methods Clinicopathological characteristics of 52 children with lgAN presented with isolated hematuria were analyzed retrospectively.Thirty-six were male,and 16 were famale;mean age of them was 10.2 years old.Results There were 78.8%of patients presented with gross hematuria,78.8%of patients with Lee′s grading of Ⅲ and 48%of patients with adverse pathological change.There were no significant difference in Lee′s grading,percentages of adverse pathological change,immunoglobulin type and lgA intensity deposited din kidney between patients with gross hematuria and patients with microscopic hematuria(P=O.227,0.845,0.276,0.957).Percentage of adverse pathological change was higher in the patients with Fg or C1q deposited in kidney(P=0.013,0.048).Conclusions Gross hematuria,Lee′s grading of Ⅲ are common in IgAN presented with isolated hematuria in children.There is often adverse pathological change in these patients.Severity of hematuria is not related to severity of pathology.Renal biopsy is necessary even in the patients with microscopic hematuria only Fg,C1q deposited in kidney may contribute to adverse pathological change.