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2003•Journal of Sun Yat-sen UniversityRequires access

Human PARP-1 Gene Polymorphisms in Chinese Han, Buyi and Zhuang Populations

Huan Tang, Sun Yat

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Abstract

Objective] To investigate nucleotide polymorphisms of five exons in human poly(ADP ribose)polymerase 1(PARP 1) gene. PCR SSCP silver staining was used to test the polymorphisms of PARP 1 gene in 634 chinese Han, Buyi and Zhuangzu people( 219, 203 and 212 respectively) . Polymorphisms of 5 exons of PARP 1 gene was not detected in 219 Han people and a polymorphisms of exon20 of PARP 1 gene was detected in 203 Buyi and 212 Zhuangzu people by PCR SSCP. Other exons were not detected. [ Conclusion] Polymorphisms may exist in exon 20 of PARP 1 gene.

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What this paper is about

Objective] To investigate nucleotide polymorphisms of five exons in human poly(ADP ribose)polymerase 1(PARP 1) gene. PCR SSCP silver staining was used to test the polymorphisms of PARP 1 gene in 634 chinese Han, Buyi and Zhuangzu people( 219, 203 and 212 respectively) . Polymorphisms of 5 exons of PARP 1 gene was not detected in 219 Han people and a polymorphisms of exon20 of PARP 1 gene was detected in 203 Buyi and 212 Zhuangzu people by PCR SSCP. Other exons were not detected. [ Conclusion] Polymorphisms may exist in exon 20 of PARP 1 gene.

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Available abstract

Objective] To investigate nucleotide polymorphisms of five exons in human poly(ADP ribose)polymerase 1(PARP 1) gene. PCR SSCP silver staining was used to test the polymorphisms of PARP 1 gene in 634 chinese Han, Buyi and Zhuangzu people( 219, 203 and 212 respectively) . Polymorphisms of 5 exons of PARP 1 gene was not detected in 219 Han people and a polymorphisms of exon20 of PARP 1 gene was detected in 203 Buyi and 212 Zhuangzu people by PCR SSCP. Other exons were not detected. [ Conclusion] Polymorphisms may exist in exon 20 of PARP 1 gene.

Key concepts: Exon, Genetics, Biology, Gene, Single-nucleotide polymorphism, Single-strand conformation polymorphism, Molecular biology, Polymerase

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