Clinical observation on iodine nutrition and thyroid dysfunction during early pregnancy

Objective To study the effect on iodine nutrition and thyroid function of pregnant women during early pregnancy. Methods 1126 cases of women who were in our hospital obstetric clinic for routine prenatal care during early pregnancy were set as research subjects,Electrochemiluminescence method was used for the determination of thyroid stimulating hormone(TSH) and free thyroxine in blood specimens. Fasting morning urine and serum samples were collected.Utilize arsenic cerium catalytic spectrophotomemc determination of iodine content in urine specimens was conducted. Results In our hospital,1126 cases of early pregnancy women,the prevalence of hyperthyroidism,subclinical hyperthyroidism,subclinical hypothyroidism,hypothyroidism was 3. 1%,4. 8%,2. 9%,5. 9% and 2. 8%,respectively. The median of urinary iodine was 145. 12 μg /L. Prevalence of thyroid dysfunction was higher in TPOAb-positive individuals(23. 3% vs.16. 3%,P 0. 05). Correlation coefficient of median urinary iodine concentration and TSH was- 0. 098. Conclusion The level of abnormal iodine nutrition directly affected the thyroid function in mother and fetus. It was recommended to grasp the level of iodine nutrition,regular monitoring of urinary iodine and thyroid function in early pregnant women. It was important to reasonable intake iodine,control of maternal hyperthyroidism,the development of pregnancy and fetal is smooth.